Endocrine Abstracts

Parathyroid localization by fine needle aspiration and parathyroid hormone (PTH) washout measurement is not a widely accepted method because of possible alterations in parathyroid histology. However, when performed with technical competence this easily available method has been praised to be an immediate confirmation of enlarged parathyroid glands found on ultrasound. We retrospectively reviewed primary hyperparathyroidism (PHPT) patients with previously performed PTH washout ...

Background: Optimal testing of beta-cell dysfunction is still elusive. Oral based solid-food tests could superiorly approximate real-life stimulation by incorporating incretin activation. Increased body fat was recently associated with better preserved beta-cell secretory response, due to gluco-lipotoxicity induced adaptation.Objective: To assess C-peptide response to standardised test meal (STM) and its dependency on subject characteristics in newly dia...

Background: Bone mineral density (BMD) measurement is an important tool for fracture risk assessment, but should be used with awareness of its performance and analysis pitfalls.Case Presentation: A 59-year-old patient underwent her first densitometry as part of a routine medical check-up. She had no previous fractures and no risk factors that could impair bone health. The results showed that her BMD was in the range of low bone mass. Four years later, de...

Background: Vascular complications are leading cause of increased morbidity and mortality of diabetic patients. Pathophysiological mechanisms included in the development and progression of diabetic complications are various and lately it has been postulated that matrix metalloproteinases MMP-2 and MMP-9, zinc-dependent endopeptidases through remodeling of extracellular matrix can contribute to the onset and progression of diabetic vascular complications. The aim of our study w...

Background: Low adiponectin levels in polycystic ovarian syndrome (PCOS) have been largely attributed to obesity which is common among these patients. In addition, evidence also suggests that low adiponectin in PCOS may be related to androgen excess in these women. Therefore, the aim of the present study was to examine the association of adiponectin levels and androgens in women with PCOS.Methods: A total of 60 women with PCOS who met the 2003 Rotterdam ...

Introduction: Secretory adrenal tumors sensitive to luteinizing hormone (LH) and/or human chorionic gonadotropin (hCG) are well documented in the literature. LH and hCG share a mutual LH/hCG receptor and a comparable physiological role.Objective: The aim of our study was to evaluate the response of adrenal steroids (cortisol, aldosterone and dehydroepiandrosterone sulphate (DHEAS)) to exogenous hCG stimulation in menopausal patients with adrenal incident...

Objective: Owing to their remarkable stability in the serum, microRNAs are being investigated as circulating cancer biomarkers. Several studies have explored their plasma or serum levels in thyroid cancer in order to differentiate benign from malignant nodules preoperatively. However, very few studies have explored the role of microRNAs to detect recurrent disease during postoperative follow-up and none of them used high through-put technologies. Recombinant human TSH (rhTSH) ...

It has been more than 70 years since the first adrenal incidentalomas (AI) were described. Most of these tumors are non-secreting, and are found in 4–7% of adult population. Patients with subclinical hypercortisolism (or autonomous cortisol secretion) (SH) are observed in 1–29% of patients with AIs. Evidence suggests that this condition may be associated with higher prevalence of diabetes, obesity, hypertension and osteoporosis.Between 1999 and...

It has been more than 70 years since the first adrenal incidentalomas (AI) were described. Most of these tumors are non-secreting, and are found in 4–7% of adult population. Patients with subclinical hypercortisolism (or autonomous cortisol secretion) (SH) are observed in 1–29% of patients with AIs. Evidence suggests that this condition may be associated with higher prevalence of diabetes, obesity, hypertension and osteoporosis.Between 1999 and...

Introduction: Women with polycystic ovary syndrome (PCOS) are at increased risk of developing insulin resistance (IR) and T2DM. In this study, we attempted to detect IR parameters that could be the best predictor T2DM in PCOS comparing to controls.Description of methods/design: In 130 women with PCOS (BMI=29.7±0.66 kg/m2; age: 25.6±0.59 years) and 41 controls (age and BMI matched) (BMI=28.5±1.35 kg/m2; age: 26.5±...